Michael D Culler Selected Research

Somatostatin (Somatotropin Release-Inhibiting Factor)

6/2021	Characterization of the ability of a, second-generation SST-DA chimeric molecule, TBR-065, to suppress GH secretion from human GH-secreting adenoma cells.
1/2020	A New Generation Somatostatin-Dopamine Analogue Exerts Potent Antitumoral Actions on Pituitary Neuroendocrine Tumor Cells.
1/2020	Therapeutic Effect of a Novel Chimeric Molecule Targeting Both Somatostatin and Dopamine Receptors on Growth Hormone-Secreting Pituitary Adenomas.
1/2020	A Somatostatin Receptor Subtype-3 (SST3) Peptide Agonist Shows Antitumor Effects in Experimental Models of Nonfunctioning Pituitary Tumors.
1/2020	TBR-760, a Dopamine-Somatostatin Compound, Arrests Growth of Aggressive Nonfunctioning Pituitary Adenomas in Mice.
1/2019	Effects of novel somatostatin-dopamine chimeric drugs in 2D and 3D cell culture models of neuroendocrine tumors.
7/2018	Somatostatin Analogue Treatment Primarily Induce miRNA Expression Changes and Up-Regulates Growth Inhibitory miR-7 and miR-148a in Neuroendocrine Cells.
11/2017	The oncogenic role of the spliced somatostatin receptor sst5TMD4 variant in prostate cancer.
1/2017	BIM-23A760 influences key functional endpoints in pituitary adenomas and normal pituitaries: molecular mechanisms underlying the differential response in adenomas.
1/2014	The truncated isoform of somatostatin receptor5 (sst5TMD4) is associated with poorly differentiated thyroid cancer.

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Michael D Culler Research Topics

Disease

28	Neoplasms (Cancer) 01/2020 - 10/2002
22	Pituitary Neoplasms (Pituitary Adenoma) 01/2020 - 02/2003
10	Body Weight (Weight, Body) 10/2013 - 01/2005
8	Prolactinoma (Prolactinomas) 01/2020 - 02/2003
8	Neuroendocrine Tumors (Neuroendocrine Tumor) 01/2020 - 01/2004
7	Adenoma (Adenomas) 01/2017 - 06/2003
6	Obesity 02/2013 - 01/2005
5	Acromegaly 06/2021 - 11/2003
5	Cachexia 01/2011 - 06/2007
4	Growth Hormone-Secreting Pituitary Adenoma 06/2021 - 06/2003
4	Thyroid Neoplasms (Thyroid Cancer) 01/2014 - 10/2002
4	Heart Failure 10/2013 - 11/2009
4	Insulin Resistance 02/2013 - 02/2005
4	Weight Gain 01/2011 - 08/2004
3	Prostatic Neoplasms (Prostate Cancer) 11/2017 - 02/2010
3	Cardiovascular Diseases (Cardiovascular Disease) 08/2011 - 03/2009
2	Carcinoid Tumor (Carcinoid) 07/2018 - 04/2005
2	Breast Neoplasms (Breast Cancer) 09/2016 - 10/2006
2	Weight Loss (Weight Reduction) 02/2013 - 10/2009
2	Dyslipidemias (Dyslipidemia) 07/2012 - 08/2011
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 09/2011 - 08/2011
2	Myocardial Infarction 01/2011 - 11/2009
2	Chronic Renal Insufficiency 01/2010 - 02/2008
2	Glioma (Gliomas) 11/2009 - 09/2008
2	Hyperinsulinism (Hyperinsulinemia) 10/2009 - 12/2008
1	Alzheimer Disease (Alzheimer's Disease) 01/2021
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021
1	Rare Diseases (Rare Disease) 01/2020
1	Retinoblastoma (Glioblastoma, Retinal) 11/2017
1	Lymphatic Metastasis 09/2016
1	Pain (Aches) 03/2014
1	Arthritis (Polyarthritis) 03/2014
1	Inflammation (Inflammations) 03/2014
1	Hyperalgesia 03/2014
1	Neoplasm Metastasis (Metastasis) 01/2014
1	Vascular Calcification 05/2013
1	Coronary Disease (Coronary Heart Disease) 05/2013
1	Hyperplasia 05/2013
1	Vascular Diseases (Vascular Disease) 05/2013
1	Atherosclerotic Plaque (Atheroma) 05/2013

Drug/Important Bio-Agent (IBA)

32	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 06/2021 - 06/2003
17	GhrelinIBA 01/2018 - 08/2004
16	Somatostatin Receptors (Somatostatin Receptor)IBA 01/2020 - 10/2002
15	Dopamine (Intropin)FDA LinkGeneric 06/2021 - 11/2003
11	Hormones (Hormone)IBA 01/2020 - 06/2003
7	TBR-760IBA 01/2020 - 01/2006
7	LigandsIBA 01/2011 - 08/2004
6	Messenger RNA (mRNA)IBA 01/2020 - 02/2003
6	Octreotide (Sandostatin)FDA LinkGeneric 01/2019 - 01/2006
5	Growth Hormone (Somatotropin)IBA 06/2021 - 08/2004
5	Proteins (Proteins, Gene)FDA Link 11/2017 - 02/2003
5	Ghrelin ReceptorsIBA 03/2015 - 01/2005
5	relamorelinIBA 10/2013 - 06/2007
5	somatostatin receptor type 1IBA 11/2009 - 06/2003
5	ProlactinIBA 05/2008 - 02/2003
4	Peptides (Polypeptides)IBA 01/2020 - 08/2004
4	Dopamine Receptors (Dopamine Receptor)IBA 01/2020 - 12/2005
4	Dopamine Agonists (Dopamine Agonist)IBA 01/2019 - 10/2006
4	Cabergoline FDA LinkGeneric 01/2019 - 01/2006
4	Biological ProductsIBA 02/2016 - 01/2004
4	Glucose (Dextrose)FDA LinkGeneric 02/2013 - 12/2008
3	Adrenocorticotropic Hormone (ACTH)FDA Link 03/2015 - 06/2005
3	cortistatinIBA 03/2014 - 06/2006
3	BIM-28125IBA 03/2013 - 01/2007
3	BIM 23206IBA 10/2012 - 01/2004
3	GlucocorticoidsIBA 09/2011 - 03/2009
3	Insulin (Novolin)FDA Link 01/2010 - 02/2005
3	BIM 23926IBA 05/2008 - 06/2003
2	Chromogranin AIBA 01/2020 - 10/2004
2	Insulin-Like Growth Factor I (IGF-1)IBA 01/2020 - 02/2005
2	Biomarkers (Surrogate Marker)IBA 09/2016 - 03/2015
2	Type 4 Melanocortin Receptor (Melanocortin-4 Receptor)IBA 02/2013 - 01/2009
2	BIM 23120IBA 10/2012 - 01/2004
2	somatostatin receptor 2IBA 10/2012 - 06/2003
2	11-beta-Hydroxysteroid Dehydrogenase Type 1IBA 07/2010 - 03/2009
2	pasireotideIBA 05/2008 - 01/2006
2	Dopamine Agents (Dopaminergic Agents)IBA 04/2007 - 04/2007
2	Pharmaceutical PreparationsIBA 10/2006 - 11/2003
2	Human Growth Hormone (Saizen)FDA LinkGeneric 01/2006 - 06/2003
2	BIM28163IBA 01/2005 - 08/2004
1	Gonadotropin-Releasing Hormone (GnRH)FDA Link 01/2021
1	Cholinergic Agents (Cholinergics)IBA 01/2021
1	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 01/2020
1	BIM23B065IBA 01/2020
1	Therapeutic UsesIBA 01/2020
1	MicroRNAs (MicroRNA)IBA 07/2018
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 09/2016
1	Small Interfering RNA (siRNA)IBA 03/2015
1	Analgesics (Analgesic Drugs)IBA 03/2014
1	prolinedithiocarbamate (PDTC)IBA 01/2014
1	Protein Isoforms (Isoforms)IBA 01/2014
1	MyostatinIBA 03/2013
1	BIM-23A761IBA 10/2012
1	Thyrotropin (Thyroid-Stimulating Hormone)FDA Link 03/2012
1	Hydrocortisone (Cortisol)FDA LinkGeneric 08/2011
1	Cortisone FDA Link 08/2011

Therapy/Procedure

16	Therapeutics 06/2021 - 10/2002
1	Duration of Therapy 01/2020
1	Drug Therapy (Chemotherapy) 09/2016
1	Spinal Injections 03/2014